Prof. Sheng-Cai Lin

Dr. Sheng-Cai Lin

Professor
School of Life Sciences
Xiamen University
BioGRAPHY

We have been interested in how glucose is sensed and regulates metabolic homeostasis. We have identified a glucose sensing pathway at the lysosome, in that the glycolytic enzyme aldolase is the sensor and transmits the signal of glucose availability to v-ATPase that serves as a central node for either activating AMPK or maintaining the activity of mTORC1. We have also identifed PEN2 as the target of metformin, revealing that the PEN2-metformin complex inhibits v-ATPase to activate AMPK for the various clinical benefits of the drug. Meanwhile, we have used aldolase as a target to screen for compounds that block aldolase from binding to its substrate FBP, and found Aldometanib as such a compound. We have shown that Aldometanib lowers blood glucose levels, allevates fatty liver, and extends lifespan.

Speaker's Schedule

Dec 22, 2022
08:40 - 09:20
Society Lecture | Live from Hangzhou site
Glucose as a messenger controlling life and death
In this seminar, I will present our view of glucose as a messenger - independently of cellular energy levels - its absence and presence activates AMPK and mTORC1 respectively. I will also present our recent work on the identification and characterization of the molecular target of metformin, and the identification of the new drug Aldometanib.
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