Research in our lab focuses on understanding the diverse signaling networks regulating essential cellular processes in normal and cancer cells. We use a multifaceted approach in which genetic models, molecular biology and pharmacological tools converge on pre-clinical models to investigate and decipher the molecular mechanisms underlying cancer initiation, progression, recurrence and metastasis, with the ultimate goal of developing safe and effective therapies for treating cancer patients. By integrating these technologies and pharmacological approaches, our lab has pioneered a new paradigm for understanding signal transduction, thus changing the way we think about important problems in applying targeted therapies to cancer.