Dr. Hong Cheng

Dr. Hong Cheng

Principal Investigator
Center for Excellence in Molecular Cell Science
Chinese Academy of Sciences
BioGRAPHY

Hong Cheng, Ph.D., is a Professor in Shanghai Institute of Biochemistry and Cell Biology. She received his undergraduate degree from China Medical University and Ph.D. degree from Kobe University, and performed postdoctoral studies at Harvard Medical School. The Cheng lab studies how nascent RNAs are sorted into the nuclear export, degradation and retention pathways. To understand this, the lab has been focused on studying three closely related aspects of gene expression: (1) The mechanism and regulation of nascent RNA sorting; (2) The complex interconnection between transcription, pre-mRNA processing and nuclear export; (3) Mechanisms and biological function of nuclear RNA degradation. Through these studies, the lab aims to reveal how the fate of nascent RNAs is determined and to understand the functional importance of RNA sorting.

Speaker's Schedule

Dec 22, 2022
15:20 - 15:40
Hangzhou Talk #23
Sorting of Nascent RNAs
Proper sorting of nascent RNAs to the productive or the destructive pathways is fundamental for ensuring accurate and precise gene expression. Nuclear speckles (NSs) are dynamic sub-nuclear structures with irregular shape present in most mammalian cells. Our recent work has suggested their roles in nascent RNA sorting. I will talk about our most recent work on NS morphology regulation and their functions in sorting RNAs for nuclear export.
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