Dr. Dong Fang

Dr. Dong Fang

Principal Investigator
Life Sciences Institute
Zhejiang University
BioGRAPHY

Dr. Dong Fang received his bachelor's degree at Tsinghua University in 2007, and received his doctor's degree at Tsinghua University in 2012. In the same year, Dr. Fang joined Mayo Clinic for his postdoctoral research. He then moved to Columbia University Medical Center as an associate research scientist in 2016. In 2018, Dr. Fang joined the Life Sciences Institute, Zhejiang University to build his research team as the principal investigator. Dr. Fang is interested in the research of epigenetics and tumors. His research is focused on how the histone modifications determine cell fate.

Speaker's Schedule

Dec 22, 2022
15:00 - 15:20
Hangzhou Talk #22
SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters
Histone marks, carriers of epigenetic information, regulate the gene expression. Studies have shown that H3K36me3 is mainly catalyzed by SETD2 to be deposited at gene body regions in mammalian cells. We uncover that in addition to gene body regions, H3K36me3 is enriched at promoters in native cells. Through screening, we identified SMYD5, which is recruited to chromatin by RNA polymerase II, as a methyltransferase catalyzing H3K36me3 at promoters.
VIEW HANGZHOU PROGRAM